Trop2 as an oncogene in gastric cancer by regulating PI3K/Akt signaling pathway
  
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DOI:10.46701/APJBG.20170217022
KeyWord:Trop2, gastric cancer, signaling pathway
                                   
AuthorInstitution
Wei Zhao Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China. Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China
Qi Tang Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Xingwang Kuai Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Xiaochen Huang Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Yaru Xu Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Tingting Yang Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Yuan Chen Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Mingjiong Zhang, Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Zhenning Qiu Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
Jin Zhu Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China. Huadong Medical Institute of Biotechniques, Nanjing , Jiangsu 210002,China.
Wenbin Huang Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Zhenqing Feng Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166,China. Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu 211166,China.
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Abstract:
      High Trop2 expression relates to aggressive tumor behavior and contributes to poor overall survival rates in gastric cancer (GC) patients. However, little is known about the molecular mechanism of Trop2 in the carcinogenesis of GC. We found that over-expressed Trop2 induced cell proliferation and clone formation, inhibited cell apoptosis and induced S cell cycle arrest in GC cell lines, meanwhile, knockdown Trop2 inhibited cell proliferation and clone formation, induced cell apoptosis and inhibits S cell cycle arrest in vitro. Moreover, Trop2 depletion inhibited tumor growth , the anti-tumor rate in this report being 22.53% in vivo. In addition, Trop2 activated the PI3K/Akt signaling pathway to promote GC malignant progression. These results indicated that Trop2 is a critical regulation factor in the progression of GC, which may help to lead a novel insight into understanding the mechanism of the Trop2 in the pathogenesis of GC.
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