The incidence and features of serological ABO subgroups among one million blood donors in Beijing
  
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DOI:10.46701/APJBG.20170217025
KeyWord:ABO subtypes, ABO discrepancy, blood donor, large-scale study
                    
AuthorInstitution
Zhiyuan Xu Blood Group Lab, Beijing Red Cross Blood Center, Beijing 100088, China.
Yushiang Lin Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Xiaofei Li Blood Group Lab, Beijing Red Cross Blood Center, Beijing 100088, China.
Haochun Chang Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Daowang Fan Blood Group Lab, Beijing Red Cross Blood Center, Beijing 100088, China.
Yan Qiu Blood Group Lab, Beijing Red Cross Blood Center, Beijing 100088, China.
Tianhong Miao Blood Group Lab, Beijing Red Cross Blood Center, Beijing 100088, China.
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Abstract:
      This study aims to determine the incidence of serological ABO subgroups from a large-scale database, along with the features of blood samples with serological ABO discrepancies. The serological ABO results of one million individuals were randomly sampled from a blood donor database in Beijing between 2009 and 2010. All samples were diagnosed by serological reverse and forward ABO typing using an automatic analyzer. The proportions of the normal ABO types were 27.28%, 31.57%, 30.56%, and 10.16% for blood types A, B, O, and AB, respectively. In samples in which ABO discrepancies or obvious weak agglutinin were identified in the forward or reverse typing, further tests to analyze the ABO subgroup were conducted. The overall incidence of ABO subgroups was 0.047%, with 14 ABO subgroups observed: A2, A3, Ax, Am, Aint, Aend, B2, B3, Bx, Bm, Bel, B(A), cisAB, and ABh. In conclusion, this study revealed the exact normal ABO and subgroup distributions in the general, healthy population of Beijing using samples from a blood donor database.
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