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| Frequencies of RhCE and Kell phenotypes in Xinjiang using a cross-minorities transfusion simulation model |
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| DOI：10.46701/APJBG.2017032017041 |
| KeyWord:Kell(K) blood type, Rh(CE) blood type, Uyghur, Kazak, antigen distribution |
| Author | Institution |
| Wei Chen |
Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China |
| Jun Wen |
Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China |
| Fei Li |
Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China |
| Changmin Wang |
Clinincal Laboratory, Xinjiang Uyghur Autonomous People′s Hospital, Urumqi, Xinjiang, 830001,China |
| Qing Li |
Department of Blood Transfusion, Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical Uninersity, Urumqi, Xinjiang, 834000, China |
| Gang Zhao |
Department of Blood Transfusion, Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical Uninersity, Urumqi, Xinjiang, 834000, China |
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| Abstract: |
| Xinjiang represents one of the richest minorities’ areas in China. This high ethnic diversity reflects in the blood groups and immune status and has a consequent impact on blood transfusions. To evaluate the risks of cross-minority transfusion in Xinjiang, we investigated the frequencies of erythrocytic Rh and K antigens among 1,073 Uyghurs and 213 Kazaks. We further reviewed the literature on the frequency of erythrocytic antigens to develop a simulation model for calculating the risk of patients in Xinjiang exposed to mismatched erythrocytic antigens. The frequencies of RhE, RhC, and K phenotypes were as follows: C antigen, 52.3% in Uyghurs and 56.8% in Kazaks; c antigen, 47.7% in Uyghurs and 43.2% in Kazaks; E antigen, 25.5% in Uyghurs and 27.2% in Kazaks; e antigen, 74.5% in Uyghurs and 72.8% in Kazaks; K antigen, 1.8% in Uyghurs and 1.8% in Kazaks. The population-adjusted cumulative match rate demonstrated that 53.3%, 51.4%, 50.6%, and 53.7% of the Uyghur, Kazak, Han, and Hui populations were recipients, respectively, although the recipients were transfused with an unknown Rh blood type. We concluded that the risks of cross-minority transfusion in Xinjiang are insignificant. The best strategy appears to be K and Rh-matched transfusions in this region due to the much higher frequency of the K antigen compared to other areas in China. |
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