Mini-review to analyse the phenotype, genotype, and alloantibody titre against Diego antigens in the Chinese population
  
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DOI:10.46701/APJBG.2017042017052
KeyWord:Diego antigens, phenotype, genotype, alloantibody
                       
AuthorInstitution
Na Ma Department of Transfusion,Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118,China;
Zhiyuan Xu Blood Group Lab, Beijing Red Cross Blood Center, Beijing, 100088, China;
Yushiang Lin Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China; The United Reference Laboratory for Blood Group Gene Detection, Jiangsu Libo Medicine Biotechnology Co., Ltd, Jiangyin, Jiangsu, 214400, China.
Haochun Chang Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China; The United Reference Laboratory for Blood Group Gene Detection, Jiangsu Libo Medicine Biotechnology Co., Ltd, Jiangyin, Jiangsu, 214400, China.
Xiaofei Li Blood Group Lab, Beijing Red Cross Blood Center, Beijing, 100088, China;
Daowang Fan Blood Group Lab, Beijing Red Cross Blood Center, Beijing, 100088, China;
Yan Qiu Blood Group Lab, Beijing Red Cross Blood Center, Beijing, 100088, China;
Tianhong Miao Blood Group Lab, Beijing Red Cross Blood Center, Beijing, 100088, China.
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Abstract:
      Diego blood antigens are important antigens in Mongoloid people and native South Americans owing to the Dia positivity rate found in these populations. However, the prevalence of Dia+ is different among native populations of America and China. Our study reviewed the genotype, phenotype, and alloantibody titre of Diego blood group antigens to explain the existence of the dosage effect for Diego antigens. The prevalence of Dia+ varied from 2.26% to 10.43% in the Chinese population was lower than that observed in Native Americans living in USA, Brazil, and Venezuela. The Di(a+b-)/Di(a+b+) ratio in the Chinese was 0.0044~0.0268, which was also lower than that observed in native Americans at 0.0203–0.1628, indicating that the major allele was Di(a+b+) in Dia+Chinese or Asians. We also collected Di(a+b-), Di(a+b+), and Di(a-b+) samples from Chinese samples to examine the agglutinin titres with anti-Dia and anti-Dib and the results supported the existence of the dosage effect for Diego antigens. The agglutinin titres of anti-Dia in Di(a+b+) specimens were lower than those in Di(a+b-) specimens, and agglutinin titres of anti-Dib in Di(a+b+) specimens were lower than those in Di(a-b+) specimens. Alloantibodies against Dia and Dib antigen are majorly responsible for haemolytic disease of the new-born and anti-Dia reactions resulting in stillborn foetus and transfusion reactions, such as fever and rash,were also reported in the Chinese population.
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