The incidence and clinical relevance of anti-HLA and/or MICA antibodies in patients with long-term survival renal allo-grafts
  
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KeyWord:HLA, DSA, MICA, renal transplantation
                       
AuthorInstitution
Dongmei Wang Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Xiaoyan Shan Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Lijun Wang Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Wei Li Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Na Liu Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Dongmei Li Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Yuanyuan Jing Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
Yanjun Jia Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China.
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Abstract:
      The purpose of this study was to analyze the incidence and clinical relevance of anti-HLA and/or MICA antibodies in renal allo-grafts transplant recipients with long-term renal survival (> 5 years). This retrospective study collected post-transplant serum samples from a total of 110 patients which were used to detect the incidence of anti-HLA and/or MICA antibodies as well as anti-HLA donor specific antibodies. Among these 110 patients, 72 patients had antibodies against HLA and/or MICA at the time of test, 61 had only anti-HLA antibodies, 31 had anti-MICA antibodies, and 38 were antibody negative. There was no difference in the number of patients developing antibodies against non-donor specific antibodies, donor specific antibodies, Class I donor specific antibodies, Class II donor specific antibodies or MICA antibodies between normal function group (serum creatinine level < 2.0 mg/dL) and dysfunction group (serum creatinine level > 2.0 mg/dL). For the serum creatinine level, estimated glomerular filtration rate and blood urea nitrogen level, patients with different antibodies were not statistically different to antibody-negative patients. Cox regression analysis showed that the type of transplantation and HLA mismatch number were significant negative risk factors for the development of anti-HLA (P < 0.05). Our results suggested that the anti-HLA antibody status has little impact on the renal graft function in the long-term survival allo-graft renal recipients.
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