The association between HLA alleles (A, B, DRB1) and HIV-1 infection/ AIDS progression in the Han Chinese population of Hubei province
  
View Full Text  View/Add Comment  Download reader
DOI:
KeyWord:HLA, HIV-1, defense gene, resistance gene, risk factor, disease progression
                 
AuthorInstitution
Wangxia Li Blood Center of Wuhan, Wuhan, Hubei 430030, China
Ru Yang Blood Center of Wuhan, Wuhan, Hubei 430030, China
Fengwu Qiu Blood Center of Wuhan, Wuhan, Hubei 430030, China
Jing Xu Blood Center of Wuhan, Wuhan, Hubei 430030, China
Gang Shen Blood Center of Wuhan, Wuhan, Hubei 430030, China
Yan Ma Blood Center of Wuhan, Wuhan, Hubei 430030, China
Hits: 14
Download times: 22
Abstract:
      The association between HLA alleles (A, B, DRB1), haplotypes and AIDS progression in HIV-1 infected patients was investigated by analyzing and comparing the differences gene frequencies of HLA alleles (A, B, DRB1) and haplotypes in HIV-1 infected and AIDS individuals in Hubei province of China. Four hundred and twenty- four HIV-1 seropositive individuals were divided into two groups: HIV-1 infected group and AIDS patient group, according to diagnostic criteria. HLA-A, B, and DRB1 allele typing was performed using polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSOP) and polymerase chain reaction-sequencing based typing (PCR-SBT) techniques. Our study revealed that B*57:01 seemed resistant to AIDS progression, and the presence of DRB1*04:05 was associated with a poor disease outcome in HIV-1 infection. These associations were independent of age, sex, and transmission route of the host. No association was observed between HLA-A, B, DRB1 homozygotes, HLA-Bw4, Bw6 serological types and AIDS progression. We concluded that HLA gene polymorphism has a significant role in HIV-1 infection/AIDS progression. This observational study may open up avenues for precision medicine in the personalized prevention and treatment of AIDS.
Close