The prevalence of alloantibody in the population of Xinjiang area of China
  
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KeyWord:alloantibody, transfusion, pregnancy
                       
AuthorInstitution
Limin Zhang Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Xiao E Department of Pharmacy, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Haiying Wang Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Mingjun Huang The Medicial Unit of Kizilsu Military Sub-District of Xinjiang Military Command of PLA, Kizilsu Kirghiz Autonomous Prefecture, Xinjiang, 845350, China
Gulinuer Kuerban Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Xiaoli Sun Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Senru Zhang Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
Yanchao Xing Department of Transfusion, The General Hospital of Xinjiang Military Command of PLA, Urumqi, Xinjiang, 830000, China
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Abstract:
      Alloantibodies are the major cause of hemolytic transfusion reaction and newborn hemolytic disease. It is highly recommended to screen alloantibodies before transfusion and pregnancy. This report applied the microcolum gel method to screen for available alloantibodies, enrolling 20,098 patients from January 2016 to December 2017 in the Xinjiang General Hospital. Seventy-two patients were found alloantibody-positive, at an overall positive rate of 0.35%. The distribution of alloantibody varied according to age, gender or treatment. The patients aged 70 plus and the patients admitted in the Department of Hematology and Department of Gynecology & Obstetrics had a higher incidence rate of alloantibodies. By using 10 screening cell panel systems, 9 types of alloantibodies including anti-D, anti-E, anti-e, anti-C, anti-c, anti-M, anti-s, anti-Fyb and anti-Ce were identified. This study suggests that the transfusion of red blood cells(RBCs) and pregnancy are the main causes of alloantibodies.
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