Association between polymorphism of the cyclin E1 gene and susceptibility to hepatocellular carcinoma in Chinese Han population of Hubei
  
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DOI:10.46701/APJBG.2019022019118
KeyWord:single nucleotide polymorphisms, hepatocellular carcinoma, second generation sequence
                                            
AuthorInstitution
Qing Liu Department of Pathology,Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071,China
Jiayan Ling Department of Traditional Chinese Medicine, the First Hospital of Wuhan, Wuhan 430022, China
Qilong Song Department of Gastroenterology, the Central Hospital of Wuhan, Wuhan 430014, China
Xiaodong Li Department of Infectious Disease, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Chizhi Zhang Department of Infectious Disease, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Mingzhong Xiao Department of Infectious Disease, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Jie Huang Department of Pathology,Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071,China
Shuxia Han Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Ling Liu Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Xiaoming Peng Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Jie Tan Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Yu Wang Department of Pathology,Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071,China
Li Ouyang Department of Pathology,Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071,China
Youyun Zhao Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
Jianhua Wu Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province Academy of TCM, Wuhan 430071, China
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Abstract:
      This study aimed to explore the relationship between CCNE1 gene single nucleotide polymorphisms (SNP rs1406 and rs3218038) and the incidence of hepatitis B virus-related hepatocellular carcinoma (HCC) in the Chinese Han population in Hubei. A total of 663 subjects, including 173 HCC patients, 172 HBV-related liver cirrhosis (LC) patients, 162 asymptomatic HBV carriers (AsC), and 156 healthy controls, participated in the study. Genotyping of CCNE1 rs1406 and rs3218038 polymorphisms was done by illumina second generation sequence method.Our findings showed that rs1406 G>T variant decreased the risk of HCC (OR 0.710, P=0.035 G vs T), and no significant differences were found between rs3218038 SNP and HCC risk using the χ2 test. Furthermore, stratified analysis revealed that differences in genotype frequencies were related to gender. Women who carried the CCNE1 GT genotype were significantly associated with a decreased risk of HCC, compared with healthy controls carrying the GG genotype (additive model, OR 0.378,P=0.030).The results suggest that the rs1406 G allele and CCNE1 rs1406 polymorphism produce an increased the risk of HCC in comparison with the T allele. Whereas, the GT genotype is a protective factor in the development of HCC in female patients.
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