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The role of free immunoglobulin light chains in serum from SLE patients with or without renal involvement |
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DOI:10.46701/APJBG.2019022019121 |
KeyWord:free immunoglobulin light chains SLE lupus nephritis |
Author | Institution |
Julio Granados |
Transplant Department, Instituto Nacional de Ciencias Medicasy Nutricion Salvador Zubiran,Mexico City 14000,Mexico |
Antonio Villa-Romero |
Research Department. Universidad Panamericana, Mexico City 14000, Mexico |
Marcos Meneses Mayo |
Universidad Anahuac, Facultad de Ciencias de la Salud, Huixquilucan, State of Mexico 14000, Mexico |
Miriam Santiago Ortíz |
Universidad Anahuac, Facultad de Ciencias de la Salud, Huixquilucan, State of Mexico 14000, Mexico |
María Fernanda García Gutiérrez |
Instituto Nacional de Ciencias Médicasy Nutricion Salvador Zubiran, Mexico City 14000,Mexico |
Víctor Hugo Tovar Méndez |
Instituto Nacional de Ciencias Médicasy Nutricion Salvador Zubiran, Mexico City 14000,Mexico |
Daniela Ruiz Gómez |
Fundacion Clinica Medica Sur, Mexico City 14000,Mexico |
Susana Maricela Hernández Doo |
Transplant Department, Instituto Nacional de Ciencias Medicasy Nutricion Salvador Zubiran, Mexico City 14000,Mexico. |
Citlaly López Orozco |
Transplant Department, Instituto Nacional de Ciencias Medicasy Nutricion Salvador Zubiran, Mexico City 14000,Mexico. |
Adriana Aguirre Telio |
Central Laboratory, Molecular Biology Area, Instituto Nacional de Ciencias Médicasy Nutricion Salvador Zubirán, Mexico City 14000, Mexico |
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Abstract: |
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease. Lupus nephritis (LN) affects 30% to 60% of adult Mexican patients. This study aimed to determine whether immunoglobulin free light chains (FLCs) constitute a biological marker for LN. FLCs have been previously studied as disease activity biomarkers, but patients with kidney damage are frequently excluded. A total of 75 consecutive SLE patients were recruited from a third-level hospital in Mexico City. Thirty-eight patients were diagnosed with LN, and the remaining 37 patients without kidney failure were included as a control group. FLCs concentration was measured by nephelometry. The results showed that SLE patients with high FLCs concentration had a higher rate of kidney failure and that the probability of renal failure increased by 2.4% for each mg/dL of κ FLCs, and 1.7% for each mg/dL of λ FLCs. This study suggests that high FLCs concentration is associated with LN, and therefore may be considered as a possible biomarker for SLE activity. |
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