Overview of the diversity of erythrocyte blood group antigens
  
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DOI:10.46701/BG.2020022020123
KeyWord:erythrocyte antigen, antibody, blood type, diversity, gene regulation
     
AuthorInstitution
Tingting Yang National Health Commission Key Lab. of Antibody Techniques, Nanjing Medical University, Nanjing 211166, China.
Zhenqing Feng National Health Commission Key Lab. of Antibody Techniques, Nanjing Medical University, Nanjing 211166, China.
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Abstract:
      During the differentiation and maturation of erythrocytes, the surface molecules of erythrocytes are gradually expressed and stabilized. These molecules are to be antigenic in addition to their functions of maintaining cell membrane structural stability, material transport and exchange of cells and signal transmission between cells. The antigenic molecules on the erythrocyte surface are called erythrocyte blood group antigens. The blood group antigens and their corresponding blood group antibodies in vivo are important indicators for clinical blood transfusion and organ transplantation, and also form the basis for research on blood group related diseases. Three hundred and sixty-eight erythrocyte blood group antigens have been confirmed so far, which are classified into 39 blood group systems, 5 blood group collections and 2 blood group series. Based on the diversity of blood group antigens and their composition of glycolipids, glycoproteins and other molecules, this study mainly reviews the classification, molecular structure, antibody response and gene regulation of blood group antigens, and explains the main reasons for the diversity of blood group antigens.
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